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The TOPPIC study, a randomized control trial (RCT) comparing mercaptopurine and placebo in preventing postoperative recurrence after surgical resection, found that smokers treated with mercaptopurine were less likely to have disease recurrence at 3 years compared to smokers treated with placebo (hazard ratio [HR], 0.13
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Regulatory Toxicology and Pharmacology: RTP , 59 (2), 197214
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