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Consequently, Parkin facilitates the ubiquitination of diverse mitochondrial proteins through a synergistic interaction with E2 ubiquitin-conjugating enzymes, culminating in the envelopment of damaged mitochondria by phosphorylated ubiquitin chains (Quinn et al., 2020)

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Research has linked smoking to an increased risk of developing age-related macular degeneration, cataract, and optic nerve damage, all of which can lead to blindness