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However, the e-cigarette market is also in some ways unique and has grown tremendously in the past decade, with tobacco industry marketing leading to e-cigarettes becoming the most popular tobacco product among youth

The FDA has spent the vast majority of its resources denigrating e-cigarettes and denying 99% of all applications from hundreds of companies seeking to market the very products, which Center for Tobacco Products Director King admitted have markedly less risk than a combustible cigarette product. This begs the question of what FDA has been doing with its remaining resources to address combustible tobacco products which FDA Commissioner Califf has said are the most dangerous

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This is not surprising, as COPD and lung cancer share several underlying disease mechanisms, such as oxidative stress and inflammation [59]