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Age: The effects of age on the pharmacokinetics of bupropion and its metabolites have not been fully characterized, but an exploration of steady-state bupropion concentrations from several depression efficacy trials involving subjects dosed in a range of 300 to 750 mg/day, on a 3-times-daily schedule, revealed no relationship between age (18 to 83 years) and plasma concentration of bupropion

doi:10.1001/jama.2014.5950

Tingen MS, Waller JL, Smith TM, Baker RR, Reyes J, Treiber FA

Changes in Cholesterol Levels Smoking negatively alters your cholesterol profile