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Furthermore, -blockers have been associated with potential effects on peripheral vascular diseases, neuroleptic-induced acute akathisia and hepatocellular carcinoma outcomes (Figure 1) ( FIGURE 1 Below are selected examples of the pleiotropic effects of -blockers: - Metabolic effects: -blockers have been linked to metabolic effects, such as weight gain and potential implications in diabetes mellitus (Tomiyama and Yamashina, 2014), while several studies have suggested that vasodilatory -blockers may have beneficial effects on glucose and lipid metabolism ( - Cardiovascular effects: certain -blockers, such as nebivolol, have vasodilatory properties, contributing to their potential to reduce systemic vascular resistance and improve endothelial function ( - Neurological effects: some studies have suggested that nonselective -blockers may have neuroprotective properties, potentially impacting neurological outcomes (Siniatchkin et al., 2007
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