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Adverse events occurred at similar rates of 2%7% in both intervention and control groups in 2 RCTs ( n = 999 and n = 300).28 , 39 In another study, both intervention and control groups had 80% 86% reporting at least 1 adverse event;27 n = 657

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Thus, the conditional recommendation against using them considers the resource implications and opportunity costs if people who smoke use these interventions instead of behavioural interventions with evidence of effectiveness