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Although in vivo energy status of specific cells and tissues is difficult to assess, the finding of decreased ATP levels and increased AMP-activated protein kinase activation in peripheral lung tissue from COPD and IPF patients suggests that energy imbalance may be important in diseases of the lung ( 3 Mitochondrial reactive oxygen species in inflammation Physiologically, ROS target and damage the components of the electron transport chain (ETC.), causing the escape of electrons and reducing molecular oxygen to form superoxide ions (Figure 1)

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