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Cell Signaling Pathways Affected by NNK and Cigarette Smoke Extract Similarly to the effect of nicotine on the Akt pathway, up-regulation of the Akt kinase phosphorylation/activation was shown to be induced by NNK and cigarette smoke extracts (CSE) in pancreatic ductal cells

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The amount and frequency of marijuana usage and the persons metabolism, body mass, and degree of hydration can all affect how long marijuana remains in urine