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In line with this, exposure to 10% CSE and 12.5% CSE induced a ~2-3 fold increase protein levels of the anti-oxidant protein Manganese Superoxide Dismutase (Mn-SOD, Figure 3C), a marker of oxidative stress, with a similar increase in Mn-SOD expression upon exposure to 10% CSE and 12.5% CSE at the mRNA level (data not shown)
& Diaz, F
Because nicotine itself leaves the human body within a matter of hours, testing directly for nicotine is highly unreliable
However, in a previous review of literature related to this topic, smoking prevalence in migraine varied between 25.9% and 51%, and thus the authors suggested smoking is more common in this group of patients [6]