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Whether for teenagers or adults, nicotine and similar drugs disrupt this development with potentially harmful effects on mental and emotional well-being in the long term

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Mucocutaneous features of Ehlers-Danlos syndrome Classic Ehlers-Danlos syndrome (MIM 130000) has the additional cutaneous features: Soft velvety skin Normal skin recoil after stretching Hyperlinear loose skin on the palms and soles Lax skin around the eyes and face forming folds in later life Lack of stretch marks in pregnancy Wounds heal slowly to leave wide 'cigarette-paper' scars Molluscoid pseudotumours - spongy blue-grey lumps over pressure points and scars Calcified spheroids - small, firm, subcutaneous nodules on forearms and shins Pigmentation following repeated bruising of easily traumatised sites Piezogenic pedal papules

Center for Drug Evaluation and Research

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First-generation devices (cig-a-likes) were mostly found to have inefficient or negligible nicotine delivery