The most important confounding factor to be highlighted for these studies is that the tobacco substrate heated in THS 2.2 differed in several important aspects from the tobacco in the reference cigarette: The tobacco substrate in the THS 2.2 test items contained added flavor ingredients, which can transfer to the aerosol, while the 3R4F reference cigarette is unflavored [4]
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High altitude medicine & biology, 2012.13(1): p