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[11] Another under-studied brain-health marker is cerebral blood flow: a study of adolescents reported that the effects of nicotine and tobacco products on brain-health markers during this neurodevelopmental period remain largely unknown and examined associations with decline in cerebral blood flow in the anterior cingulate cortex (ACC) and precuneus/posterior cingulate cortex (PCC)

These so-called second-line tobacco treatment medications, such as clonidine and nortriptyline, are used less often and do not have an official FDA indication for tobacco cessation