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Although previous dogma claim that innate leukocytes such as monocytes and neutrophils are first responders to challenges with limited modulatory roles nor memory, recent studies suggest that more complex programming and memory dynamics of neutrophils may exist ( At the molecular level, our data reveal that TPM skews neutrophil function through reducing STAT1-mediated expression of inflammatory mediators as well as critical anti-bacterial components such as iNOS and NADPH oxidase components, both of which are important for the anti-bacterial function of neutrophils ( Statements Ethics statement This study was carried out in accordance with the recommendations of Virginia Tech Institutional Guideline for proper usage of animals

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