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The mechanisms behind smoking cravings Nicotine is a psychoactive substance, meaning it acts on the brain and alters the functioning of neural circuits, driving smokers to continuously seek their dose of nicotine
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Nicotine pharmacology During cigarette smoking, nicotine is inhaled and rapidly absorbed into the pulmonary circulation, reaching the arterial circulation and brain within 1020 seconds and peak concentration within a few minutes [5]
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