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Upon the binding of BMP ligands to type-II receptors on the cell membrane surface, the constitutive activity of their serine/threonine kinase domains is activated, which in turn mediates the phosphorylation of the intracellular GS domain of type-I receptors to activate type-I receptor kinases

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SARS-CoV nucleocapsid protein (N protein) activates IL6 expression in a concentration-dependent manner, which requires NF-B binding cis-acting element at the IL6 promoter region [54]

A note on the studys methodology and its major limitations This study uses a combination of qualitative and quantitative data