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TLS addresses the challenges of accessing hidden populations, and approximates probability sampling methods and therefore, allows statistical inferences to a larger population [2426]

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Employer Screening: Many companies, especially in healthcare and safety-sensitive roles, include nicotine in their protocols to maintain a drug-free or tobacco-free workplace, often to reduce health costs or promote wellness programs

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The gas phase of cigarette smoke contains large amounts of free radicals and pro-oxidants such as NO, nitrogen dioxide (NO 2 ), phenols, and nitrosamines