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Consequently, safety concerns exist regarding e-cigarette user exposure to harmful and potentially harmful constituents (HPHCs), including nicotine, which has the potential to cause addiction and other adverse events [14]

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French resistance leader Charles DeGaulle was famous for this: During an attack by pro-fascist snipers following the liberation of Paris, witnesses recalled seeing General Charles de Gaulle striding unflinchingly through a hail of bullets "as if he led a charmed life." Later, in the early 60s, an assassination attempt was made against DeGaulle by the reactionary OAS (Secret Army Organization) in an effort to prevent him from abandoning Algeria

In contrast, the majority of the studies with other study designs reported a higher risk of cancer following e-cigarette exposure (Figure 2)