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Correlations with CPD were slightly lower for 3OH-cotinine (men 0.34, women 0.32) (Table S1) and the sum of cotinine and 3OH-cotinine (men 0.39, women 0.37)

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The strongest evidence for the self-medication hypothesis comes from the neurophysiological findings of sensory processing deficits in pre-pulse inhibition and suppression of P50-evoked potential, and abnormalities in anti-saccadic eye movement tests (Kumari Reference Kumari and Postma2005)

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