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However, the combination of NRT and bupropion is more effective for the treatment of smoking in patients with schizophrenia, but the abstinence rate was not substantially higher than the rate produced by bupropion alone in patients with depression [6, 22]

In conclusion, this study demonstrated the detrimental effects of nicotine exposure on spermatogenesis, disrupting the testicular microenvironment and impairing the critical transition from histone to protamine in sperm chromatin

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