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While data are still emerging about the specific impacts of the virus on people who use tobacco, conclusive evidence shows that smoking weakens the immune system and increases the risk of respiratory infections

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Its unknown exactly when tobacco reached Japan

Nat Rev Cancer (2009) 9(2):95107.10.1038/nrc2584 38 LiYChangSCNiuRLiuLCrabtree-IdeCRZhaoBet alTP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population