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The incidence of the individual adverse reactions (i.e., insomnia, nausea, headache, diarrhea, vomiting, dizziness, and irritability) did not exceed 5.3% in any treatment group and usually resolved after 1 week post-discontinuation

Controlled UVA exposure (1015 minutes, 23 sessions weekly) during the first 4 weeks accelerates melanogenesis by 3-fold compared to Melanotan-1 alone, per British Journal of Dermatology data