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Furthermore, a growing body of evidence suggests changes in enzyme activity, possibly through epigenetic mechanisms, with persistent accelerated metabolism even after smoking cessation (Hirota et al., 2008

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1, by continuous smoking of four cigarettes of Hi-Lite brand which gave the virtual tar concentration of approximately 10 mg/ml PBS

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38,39 Including the current study, 4 longi- tudinal 8,13,28 and many cross-sectional studies 5,35,40-43 have reported withdrawal symptoms in nondaily smokers