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This leads to chronic inflammation as the body tries endlessly to heal, meaning lots of cell division and so lots of opportunities for cancer-causing mutations to accumulate over years of infection. The flukes toxic toilet habits then add insult to injury

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Specifically, activation of the TRPA1 receptor could be significant in several pathological situations given that it is known to be stimulated by a multitude of environmental irritants (including constituents of air pollution and burning vegetation), as well as endogenous products of oxidation which can be generated in the airways by inhalation of pollutants or during inflammation (Bessac et al., 2008