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In parallel, nicotine-related alterations in GABA signaling observed ex vivo were associated with enhanced diazepam-induced inhibition of lateral VTA DA neurons in vivo

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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Dwyer JB, McQuown SC, Leslie FM

This seems like a very drastic step, but following on from the gradual restrictions that are applied to cigarettes, it is not unforeseeable

On the other hand, ceramide subclasses derived from dihydrosphingosine and phytosphingosine were unchanged or decreased