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Common side effects Most patients experience mild side effects that improve over time: Headache Nausea (though usually less than with tablets) Constipation Unusual tiredness or drowsiness Dizziness Dry mouth Sleep problems Mouth-related effects from sublingual use: Mild irritation under the tongue Altered taste Increased saliva production initially Serious side effects and adverse reactions requiring immediate medical attention Most people tolerate Suboxone sublingual film well, but like any medication, it can sometimes cause serious side effects