21) and that 9,000 Americans die of diabetes due to smoking each year (Ref
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1 2 3 "Rules and Regulations Implementing Republic Act 9211, Otherwise Known as the Tobacco Regulation Act of 2003" (PDF)
Indeed, although many studies have clearly shown that several interventions including pharmacological therapy and lifestyle modifications improve endothelial function under the condition of relatively mild vascular endothelial dysfunction [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35], we have shown that advanced endothelial dysfunction is not reversible even by appropriate pharmacological therapy [94]
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