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Finally, reversing the order of administration by giving a known promoter prior to an initiator may prevent the expression of carcinogenic activity on the part of the initiator

"Smoking even two to five cigarettes a day can more than double your risk of any type of heart disease and raise your risk of death from any cause by 60% compared to people who never smoked," the association stated in the release

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Reynolds Tobacco Company, a subsidiary of Reynolds American Inc