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Given that we can comfortably say that almost without exception, all e-cig users are former or current smokers, then the relative harm to the vast majority of users from e-cigs is actually a *negative* harm that is, a net benefit to their health

Free radicals, nicotine, and carbon monoxide (CO) are believed to be the most important for pharmacological actions 21

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however, data from the pilot were excluded from the final analysis