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17 The exact mechanism of action is not certain, however, it likely weakly inhibits dopamine and noradrenaline reuptake in the brain and acts as a nicotinic acetylcholine receptor antagonist

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COPD, which includes emphysema and chronic bronchitis, is a major contributor to morbidity and mortality in all countries, and is the fourth largest cause of death in the United States [21, 22]

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& Henningfield, J

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