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On average, smokers systemically absorb 10% of the nicotine contained in the rod, with a typical systemic intake of 12 mg of nicotine per cigarette.13 We made an initial estimate that reducing the total nicotine content of cigarettes to 0.5 mg per rod would minimise the addictiveness of cigarettes.10 It was assumed that these doses would not produce psychoactive and rewarding effects, but such effects might occur at lower doses in non-tolerant children and adolescents.14 A more recent analysis suggests that the maximum allowable nicotine content per cigarette that minimises the risk of central nervous system effects contributing to addiction may be lower.8 Sofuoglu and LeSage reviewed the question of nicotine addiction threshold as a target for tobacco control.15 They noted the challenges of determining daily addiction thresholds and suggested that the threshold for nicotine regulation should be based on the amount of nicotine per unit dose (eg, per puff from a cigarette) that produces reinforcementthe nicotine reinforcement threshold

The findings have implications for anti-smoking policies, Cawley said

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If the swelling persists or worsens, it is important to consult a healthcare provider