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Carcinogenicity of SLT Oral administration: Swiss mice fed an extract of chewing tobacco in diet developed lung adenocarcinoma and hepatocellular carcinoma,[] while Swiss mice, Sprague-Dawley rats, and hamsters fed black or brown masheri developed forestomach papillomas.[] Gavage feeding of extracts of chewing tobacco or gutka alone induced forestomach and esophageal papillomas in a small number of animals, while similar treatment increased the tumor yield in animals initiated with diethylnitrosamine

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for a total of 23 1/2 inches

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