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One example he cites is a 2019 randomized controlled trial by Smith et al

In practical terms, identifying and understanding the neurobiological underpinnings of the sex differences in smoking behavior, by identifying unique dopamine signatures of nicotine-dependence in men and women could provide paths for developing and testing gender-sensitive medications and other approaches for quitting smoking

Effect of smoking on blood pressure Am Heart J 1974 87 : 558564 Green MS, Jucha E, Luz Y

Insanity, as a result of too many cigarettes (or cigars)