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The horizontal axis is linear in time, defined as the number of years between the midpoints of the participants period and the first period, and the vertical axis is logarithmic in serum cotinine concentration (ng/mL)
Cotinine , nicotine's primary metabolite, has a significantly longer half-life of about 15 to 20 hours
The warnings and precautions sections of the drugs prescribing information have been updated, and FDA recommends that (1) patients tell their health care providers about any history of psychiatric illness before starting varenicline and (2) clinicians and patients monitor for changes in mood and behavior during treatment with varenicline
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