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The most recent article on the topic by Abouk and Adams (2017) concluded that e-cigarette sales restrictions were associated with reduced adolescent smoking through 2014, while two earlier articles by Friedman (2015) and Pesko and colleagues (2016) came to the opposite conclusion, that e-cigarette sales restrictions were associated with higher levels of adolescent smoking through 2013

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Methacholine and benzene are well known irritants that form during the transformation from liquid to vapor