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Machine-made cigarillos use precise tobacco cuts and consistent packing, while hand-rolled small cigars might feature long-filler tobaccos that create a more nuanced smoking experience as different leaves burn at varying rates

Smoking affects gum health by reducing blood flow to the gums, weakening the immune system, increasing the risk of gum disease, and causing treatment complications

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In a few cases, particularly in the NP, our rates were lower, likely due to the presence of non-notochordal cells (Table 1)