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Signaling network analysis was conducted using GeneMANIA ( to analyze interactions between the cigarette smoke-induced changes of eight growth factors (AR, EGFR, IGF-1, M-CSF/CSF1, NT-4, PDGF-AA, TGF3, and VEGFR3) and signaling networks that regulate self-renewal, pluripotency/stemness, or migratory capacity

Other factors, such as age, height, weight, BMI, years of smoking, time since the last cigarette, puffs, smoking duration, ethnicity, and type of cigarettes used to smoke, showed no significant difference between light smokers and heavy smokers

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Oh, he would talk about it all the time