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reported that Astaxanthin binds with SIRT1, inhibits Nrf2-modulated oxidative stress, and regulates NF-B-related inflammatory responses in CS-induced emphysema mouse models and human bronchial epithelial cells [231]

In TNBS-induced CD-like colitis, cigarette smoke upregulates GPR15 on T cells, promoting Th17 differentiation and aggravating the disease

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They include: Red, itchy patches of skin on light skin