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The availability of less harmful options for nicotine consumption accelerated the decades-long trend of declining smoking prevalence

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[52] Stimulation of the brain [edit] Nicotine is a parasympathomimetic stimulant [8] that binds to and activates nicotinic acetylcholine receptors in the brain, [9] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [10] and several neuropeptides, including proopiomelanocortin-derived -MSH and adrenocorticotropic hormone

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Symptom Check: What to Look Out For Most of the above conditions share a few key symptoms