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104, 105 TLR2 recognizes not only peptidoglycans from Gram-positive bacteria and bacterial lipopeptides, but also endogenous danger signals, such as 70-kDa heat-shock protein (the latter is known to be released in smoke-exposed airways 104 )

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The lethal consequences of smoking have been known to tobacco corporations for decades, yet they continue these activities, with full knowledge that millions of deaths will be caused by the ordinary use of cigarettes