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Chewing tobaccos popularity has seen a decline over the years, but its still holding steady among specific groups

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It is characterized by inflammation in the small intestines

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Moreover, even by itself, nicotine is a sympathomimetic drug that elicits hemodynamic and metabolic changes that could increase the risk of acute cardiovascular events such as arrhythmias or plaque rupture and chronically increase cardiovascular disease risk by inducing dyslipidemia