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1847 was the year when Philip Morris was established in the UK

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Participants were to attend all three sessions, but were allowed to continue to come to sessions as long as they wished

The lowest concentration which elicited a significantly different response compared to the control was identified as the Lowest Observed Effect Concentration (LOEC), whilst the highest concentration which did not cause a significantly different response compared to the control was identified as the No Observed Effect Concentration (NOEC)

You know very well that the simple designs also require some planning