Classic EDS is inherited in an autosomal dominant manner and is caused by mutations in COL5A1 or COL5A2, which encode the alpha-1 and alpha-2 chains, respectively, of collagen type V.1 The disease is characterized by skin hyperextensibility, joint hypermobility and associated complications (luxations, pain, early osteoarthritis), and other clinical characteristics that are reviewed in a recent international consensus paper.1 Dermatologic manifestations of classic EDS include skin hyperextensibility and abnormal scarring, which results the formation of atrophic scars with a cigarette-paper-like appearance
Additionally, there is an increasing number of studies identifying new biomarkers for EMT in COPD
In some cases, the joint pain can be severe and last for months or years
First, we investigated OXPHOS levels and observed that protein levels of Complex V F1 were not significantly different in PBECs from non-smokers compared to smokers
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The demand quickly grew as tobacco, referred to as "brown gold", revived the Virginia joint stock company from its failed gold expeditions
