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Its caused by the bacteria treponema pallidum

Jatlaoui TC, Wiltz JL, Kabbani S, Siegel DA, Koppaka R, Montandon M, Adkins SH, Weissman DN, Koumans EH, OHegarty M, et al

Toxic chemicals found in cigarettes can damage or disrupt DNA and produce mutations (changes) that can cause cancer

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