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Cannabis may affect the metabolism of SNRIs, leading to higher or lower medication levels in different people

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The Centers for Disease Control (CDC) has reported that smoking is responsible for just about one out of every five deaths in the U.S., which is more than the mortality rate of car accidents, firearm incidents, alcohol use, illegal drug use, and HIV combined

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Publicized large arrests also provide a lengthy stream of anecdotal evidence of an active illicit market