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Eicosanoids such as 15-hydroxy eicosatetraenoic acid (15 HETE) and 6-keto Prostaglandin PGF1, PGF2, and PGF2 are decreased by nicotine on the rectal mucosa but not the caecal mucosa

To investigate the sources of heterogeneity, we performed subgroup analyses based on different criteria, including country income categories (HICs versus LMICs), policy implementation time (pre-2008 versus post-2008, following the introduction of the World Health Organizations MPOWER package in 2008) and policy evaluation timing relative to its introduction (within 15 months versus more than 16 months, using the median value)

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