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[3] Activation-dependent agents are relatively inert in their original form, but are bioactivated in the body into metabolites or intermediaries capable of damaging human DNA

These included targeted advertising, brand loyalty programs and the use of psychology in product packaging and placement

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The average excise tax (i.e., targeted tax levied on certain goods like cigarettes) is significantly lower in Tobacco Nation ($.98) than in the rest of the U.S

The financial and behavioral gravity of purchasing a larger quantity also promotes binge use rather than moderation, accelerating the development of cocaine use disorder