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It has been shown that rs16969968/rs1051730 explains more of the variance in an objective measure of tobacco exposure, cotinine (4%), than in self-reported cigarettes per day (1%).31 ,35 This appears to be why the variant shows a much stronger association with lung cancer than predicted from the observed associations with self-reported cigarettes per day.31 Therefore if higher levels of smoking did cause depression or anxiety, we might expect the effects of rs16969968/rs1051730 to be considerably larger than those seen observationally per cigarette per day

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