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Peer review Peer review information Nature Health thanks the anonymous reviewers for their contribution to the peer review of this work

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10 slides of each lung were examined by Olympus BX41 microscope and images were acquired by Olympus DP72 digital camera, followed by image analysis using ImageJ software (available from To quantify emphysema, alveolar enlargement and destruction were evaluated by the mean linear intercept (Lm) in 10 randomly selected fields per slide

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