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Global assessments of smoking rates might be challenged on several grounds

These variations highlight the importance of assessing emerging potential risk factors, including e-cigarette use, which may contribute to COPD risk beyond traditional smoking

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Nicotine, Carcinogen, and Toxin Exposure in Long-Term Ecigarette and Nicotine Replacement Therapy Users: A Cross-Sectional Study. Annals of Internal Medicine 166

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A key strength of this approach was the use of an independent second cohort of a nicotine intervention and measures of within-subjects change which corroborated the results of our data-driven analysis in the first cohort