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Although smoking can increase the likelihood of clotting, it does not actually thin the blood

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Tobacco smoke is a complex aerosol which includes condensed liquid droplets (the particulate matter (PM) or tar) suspended in a mixture of volatile and semi-volatile compounds and combustion gases (the gas fraction)

2) the genetic variations have no direct impact on the outcome, otherwise it becomes challenging to discern whether the outcome is caused by the exposure or directly by the IV